The role of diet in Multiple Sclerosis

Can dietary changes help Multiple Sclerosis?

Multiple sclerosis (or MS) is a chronic, sometimes progressive condition, that affects the nerves in our body, leading to many neurological symptoms including weakness, balance problems, changes in sensation, visual problems and more.

It's an autoimmune disease, where the body attacks the protective sheath on nerve fibres (the myelin sheath). This damages and scars the sheath, and potentially the underlying nerves, meaning that messages travelling along the nerves become slowed or disrupted.

For many years there was thought to be no way to prevent MS, and the only options for treatment were medications

Yet more recently several studies have looked at the role of diet and MS, and found that it may play a small but significant role, alongside medical treatment.

One trial looking at the link between diet and MS looked at the MRI (brain) scans of people with MS, and compared the extent of MS changes in the brain, with people's diet.
It found that people who followed a MIND diet (a brain healthy diet designed to reduce dementia symptoms) had significantly less MS changes on MRI scans than those who followed typical Western diets

The MIND diet is a version of the Mediterranean diet which is high in antioxidants, predominantly plant based, and high in leafy greens, berries, vegetables and nuts, as well as fish. It limits red meat, dairy, processed foods, and saturated fat. It's a brain focused version of an anti-inflammatory diet that we talk about in other posts, and specifically includes foods known to promote brain health. It's also proven to help overall health, in particular brain function, heart health, blood pressure, cholesterol, weight, and diabetes

Previous studies looking at MS and diet have also found a similar pattern :
✔️high saturated fat diets were associated with higher rates of MS in population studies
✔️ a trial of 61 MS patients using a low fat, plant based diet showed improved fatigue as well as improved cholesterol and insulin levels
✔️the 'Swank' diet, which followed MS patients over 50 years, showed reduced MS exacerbations, lower symptoms, and improved life expectancy on a low fat mostly plant based diet
✔️a 2017 Italian study showed significantly reduced symptoms in 20 MS patients over a 12 month period in people following a high plant food /low protein diet

Multiple observational studies have also shown a link between high dairy intake and higher rates of MS, meaning that some experts suggest avoiding dairy if you have MS, or have a high risk of MS.

It's also known that having low vitamin D levels may increase the risk of developing MS, with a strong correlation between living in countries further away from the equator, and higher rates of MS
✔️the nurses health study showed a 40% reduction in MS rates in those who took vitamin D supplements
✔️trials where vitamin D was used to avoid deficiency (serum level >50nmol/L) showed slower MS progression and reduced disability

The key factor in common with all of the studies above, is that they emphasise high intake of whole plant foods, avoiding processed food and added sugar, and limiting saturated fat, red meat and dairy

☀️As Michael pollan famously said 'eat whole foods, not too much, mostly plants'!!

https://www.google.com/amp/s/medicalxpress.com/news/2021-06-mind-diet-brain-people-multiple.amp

van der Mei IA, Ponsonby AL, Dwyer T, et al. Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. BMJ. 2003;327(7410):316. [PMID:12907484]

Munger KL, Zhang SM, O'Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology. 2004;62(1):60-5. [PMID:14718698]Salzer J, Hallmans G, Nyström M, et al. Vitamin D as a protective factor in multiple sclerosis. Neurology. 2012;79(21):2140-5. [PMID:23170011]

Mokry LE, Ross S, Ahmad OS, et al. Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study. PLoS Med. 2015;12(8):e1001866. [PMID:26305103]

Franklin GM, Nelson L. Environmental risk factors in multiple sclerosis: causes, triggers, and patient autonomy. Neurology. 2003;61(8):1032-4. [PMID:14581658]

Mohr DC, Hart SL, Julian L, et al. Association between stressful life events and exacerbation in multiple sclerosis: a meta-analysis. BMJ. 2004;328(7442):731. [PMID:15033880]

Ackerman KD, Stover A, Heyman R, et al. 2002 Robert Ader New Investigator award. Relationship of cardiovascular reactivity, stressful life events, and multiple sclerosis disease activity. Brain Behav Immun. 2003;17(3):141-51. [PMID:12706412]

Thacker EL, Mirzaei F, Ascherio A. Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. Ann Neurol. 2006;59(3):499-503. [PMID:16502434]

Lünemann JD, Münz C. Epstein-Barr virus and multiple sclerosis. Curr Neurol Neurosci Rep. 2007;7(3):253-8. [PMID:17488592]

Bagos PG, Nikolopoulos G, Ioannidis A. Chlamydia pneumoniae infection and the risk of multiple sclerosis: a meta-analysis. Mult Scler. 2006;12(4):397-411. [PMID:16900753]

Munger KL, Peeling RW, Hernán MA, et al. Infection with Chlamydia pneumoniae and risk of multiple sclerosis. Epidemiology. 2003;14(2):141-7. [PMID:12606878]

Sotelo J, Martínez-Palomo A, Ordoñez G, et al. Varicella-zoster virus in cerebrospinal fluid at relapses of multiple sclerosis. Ann Neurol. 2008;63(3):303-11. [PMID:18306233]Hernán MA, Zhang SM, Lipworth L, et al. Multiple sclerosis and age at infection with common viruses. Epidemiology. 2001;12(3):301-6. [PMID:11337603]

Jagannath VA, Filippini G, Di Pietrantonj C, et al. Vitamin D for the management of multiple sclerosis. Cochrane Database Syst Rev. 2018;9:CD008422. [PMID:30246874]

Ascherio A, Munger KL, White R, et al. Vitamin D as an early predictor of multiple sclerosis activity and progression. JAMA Neurol. 2014;71(3):306-14. [PMID:24445558]

Alharbi FM. Update in vitamin D and multiple sclerosis. Neurosciences (Riyadh). 2015;20(4):329-35. [PMID:26492110]Schwarz S, Leweling H. Multiple sclerosis and nutrition. Mult Scler. 2005;11(1):24-32. [PMID:15732263]

Das UN. Is there a role for saturated and long-chain fatty acids in multiple sclerosis? Nutrition. 2003;19(2):163-6. [PMID:12591552]Malosse D, Perron H, Sasco A, et al. Correlation between milk and dairy product consumption and multiple sclerosis prevalence: a worldwide study. Neuroepidemiology. 1992;11(4-6):304-12. [PMID:1291895]

Ghadirian P, Jain M, Ducic S, et al. Nutritional factors in the aetiology of multiple sclerosis: a case-control study in Montreal, Canada. Int J Epidemiol. 1998;27(5):845-52. [PMID:9839742]

Swank RL, Grimsgaard A. Multiple sclerosis: the lipid relationship. Am J Clin Nutr. 1988;48(6):1387-93. [PMID:3202088]

Calder PC. N-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr. 2006;83(6 Suppl):1505S-1519S. [PMID:16841861]

Besler HT, Comoğlu S. Lipoprotein oxidation, plasma total antioxidant capacity and homocysteine level in patients with multiple sclerosis. Nutr Neurosci. 2003;6(3):189-96. [PMID:12793524]

Yadav V, Marracci G, Kim E, et al. Low-fat, plant-based diet in multiple sclerosis: A randomized controlled trial. Mult Scler Relat Disord. 2016;9:80-90. [PMID:27645350]

Swank RL, Goodwin J. Review of MS patient survival on a Swank low saturated fat diet. Nutrition. 2003;19(2):161-2. [PMID:12591551]

Saresella M, Mendozzi L, Rossi V, et al. Immunological and Clinical Effect of Diet Modulation of the Gut Microbiome in Multiple Sclerosis Patients: A Pilot Study. Front Immunol. 2017;8:1391. [PMID:29118761]

Guggenmos J, Schubart AS, Ogg S, et al. Antibody cross-reactivity between myelin oligodendrocyte glycoprotein and the milk protein butyrophilin in multiple sclerosis. J Immunol. 2004;172(1):661-8. [PMID:14688379]

Maclean CH, Issa AM, Newberry SJ, et al. Effects of omega-3 fatty acids on cognitive function with aging, dementia, and neurological diseases. Evid Rep Technol Assess (Summ). 2005. [PMID:15777112]

Farinotti M, Vacchi L, Simi S, et al. Dietary interventions for multiple sclerosis. Cochrane Database Syst Rev. 2012;12:CD004192. [PMID:23235605]

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